Pub. Date : 2003 Dec
PMID : 14713576
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CRABP I expression and the mediation of the sensitivity of human tumour cells to retinoic acid and irradiation. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 2 | PURPOSE: To examine the role cytoplasmic retinoic acid binding protein type 1 (CRABP I) and retinoic acid receptor beta 2 (RAR-beta 2) in mediating radiosensitization of human tumour cells in vitro by retinoic acid. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 3 | The retinoic acid-sensitive cell line HTB35 was transfected for inducible CRABP I overexpression to test the role of this protein in modulating the sensitivity to retinoic acid and radiation as well as in regulating RAR-beta 2 and cyclin D1 expression. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 4 | RESULTS: The basal CRABP I level clearly correlated with the clonogenic survival of tumour cells and normal fibroblasts after treatment with retinoic acid and ionizing irradiation (IR). | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 5 | Cells expressing high basal CRABP I were more resistant to combined retinoic acid radiation treatment than cells with low basal expression. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 6 | Overexpression of CRABP I in retinoic acid-sensitive HTB35 cells induced a retinoic acid-insensitive phenotype resistant to combined treatment with retinoic acid and radiation. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 7 | CRABP I overexpression resulted in stimulated cyclin D1 expression indicating the dependency of this cell cycle control protein on retinoic acid metabolism. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 8 | CONCLUSION: CRABP I plays an important role not only in mediating the retinoid effects, but also in modulating the radiation sensitivity of tumour cells after combined retinoic acid radiation treatment. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |