Pub. Date : 2003 Dec
PMID : 14713310
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated the role of protein kinases in the induction of these AMPH-mediated events by using inhibitors of protein kinase C (PKC), mitogen activated protein kinase (MAP kinase) or protein kinase A (PKA). | Amphetamine | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 2 | On the contrary, a selective PKA inhibitor, 100 micro m Rp-8-Br-cAMPS, blocked only the development of AMPH-stimulated DA release but not the neurite outgrowth. | Amphetamine | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 3 | Treatment of the cells with acute AMPH elicited an increase in the activity of PKC and MAP kinase but not PKA. | Amphetamine | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 4 | These results demonstrated that AMPH-induced increases in MAP kinase and PKC are important for induction of both the enhancement in transporter-mediated DA release and neurite outgrowth but PKA was only required for the enhancement in AMPH-stimulated DA release. | Amphetamine | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 5 | These results demonstrated that AMPH-induced increases in MAP kinase and PKC are important for induction of both the enhancement in transporter-mediated DA release and neurite outgrowth but PKA was only required for the enhancement in AMPH-stimulated DA release. | Amphetamine | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |