Title : Mutational analysis provides molecular insight into the carbohydrate-binding region of calreticulin: pivotal roles of tyrosine-109 and aspartate-135 in carbohydrate recognition.

Pub. Date : 2004 Jan 13

PMID : 14705935






4 Functional Relationships(s)
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1 To provide further insight into these lectin-glycan interactions, we are investigating the interaction of CRT with various sugars. Sugars calreticulin Homo sapiens
2 We have earlier modeled the complex between CRT and the Glc(1)Man(3) tetrasaccharide, a derivative of the native Glc(1)Man(9)GlcNAc(2) sugar moiety. Sugars calreticulin Homo sapiens
3 Here, we have systematically mutated the residues implicated by the model in the interaction of CRT to its sugar substrates and categorized the role played by each of the subsites of calreticulin toward the glycan binding. Sugars calreticulin Homo sapiens
4 These studies provide detailed molecular insight into the sugar binding specificity of CRT. Sugars calreticulin Homo sapiens