Title : Mutational analysis provides molecular insight into the carbohydrate-binding region of calreticulin: pivotal roles of tyrosine-109 and aspartate-135 in carbohydrate recognition.

Pub. Date : 2004 Jan 13

PMID : 14705935






2 Functional Relationships(s)
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1 The mutation of residues from the primary binding site of CRT, i.e., those interacting with glucose, appears to be far less tolerated as compared to mutations in residues that interact with the mannose residues of the glycan. Glucose calreticulin Homo sapiens
2 Also, methyl-2-deoxy-glucopyranosyl-alpha(1-->3)-mannopyranoside failed to bind, asserting to the significance of the interactions between the primary binding site of CRT and the 2"-OH of the glucose residue of the oligosaccharide substrate in generating specificity for this recognition. Glucose calreticulin Homo sapiens