Pub. Date : 2004 Jan
PMID : 14704128
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIM: To study the effects of acetazolamide and anordiol on osmotic water permeability in aquaporin 1 (AQP1)-cRNA injected Xenopus oocyte and their mechanisms. | Acetazolamide | aquaporin 1 (Colton blood group) L homeolog | Xenopus laevis |
| 2 | AIM: To study the effects of acetazolamide and anordiol on osmotic water permeability in aquaporin 1 (AQP1)-cRNA injected Xenopus oocyte and their mechanisms. | Acetazolamide | aquaporin 1 (Colton blood group) L homeolog | Xenopus laevis |
| 3 | The effects of acetazolamide and anordiol on the water transport function of AQP1 were observed by assaying the osmotic swelling of oocytes. | Acetazolamide | aquaporin 1 (Colton blood group) L homeolog | Xenopus laevis |
| 4 | RESULTS: After incubation for 15 min or 72 h, acetazolamide, a carbonic anhydrase inhibitor, equally reduced the water permeability of AQP1-cRNA injected oocyte in a dose-dependent manner. | Acetazolamide | aquaporin 1 (Colton blood group) L homeolog | Xenopus laevis |
| 5 | CONCLUSION: Both acetazolamide and anordiol inhibited the osmotic water permeability of AQP1-cRNA injected oocyte, but their mechanisms were different. | Acetazolamide | aquaporin 1 (Colton blood group) L homeolog | Xenopus laevis |
| 6 | Acetazolamide functionally inhibited the osmotic water permeability of AQP1, whereas anordiol primarily decreased the amount of AQP1 protein in the oocyte membrane. | Acetazolamide | aquaporin 1 (Colton blood group) L homeolog | Xenopus laevis |