Title : Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae.

Pub. Date : 2004 Jan 5

PMID : 14697759






2 Functional Relationships(s)
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1 We previously reported that yeast cells deficient in the two AP endonucleases (apn1 apn2 double mutant) are extremely sensitive to killing by a model DNA alkylating agent methyl methanesulfonate (MMS) and that this sensitivity can be reduced by deleting the MAG1 3-methyladenine DNA glycosylase gene. Methyl Methanesulfonate DNA-(apurinic or apyrimidinic site) lyase APN1 Saccharomyces cerevisiae S288C
2 We previously reported that yeast cells deficient in the two AP endonucleases (apn1 apn2 double mutant) are extremely sensitive to killing by a model DNA alkylating agent methyl methanesulfonate (MMS) and that this sensitivity can be reduced by deleting the MAG1 3-methyladenine DNA glycosylase gene. Methyl Methanesulfonate DNA-(apurinic or apyrimidinic site) lyase APN1 Saccharomyces cerevisiae S288C