Title : Differential apoptotic response to the proteasome inhibitor Bortezomib [VELCADE, PS-341] in Bax-deficient and p21-deficient colon cancer cells.

Pub. Date : 2003 Nov-Dec

PMID : 14688479






4 Functional Relationships(s)
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1 In this study, we investigated the role of p53 and its downstream targets in bortezomib-induced apoptosis in HCT116 human colon cancer cells. Bortezomib tumor protein p53 Homo sapiens
2 We demonstrated that bortezomib induced p53, and activated its downstream genes p21, PUMA and Bax in a p53-dependent fashion. Bortezomib tumor protein p53 Homo sapiens
3 We demonstrated that bortezomib induced p53, and activated its downstream genes p21, PUMA and Bax in a p53-dependent fashion. Bortezomib tumor protein p53 Homo sapiens
4 These results indicate that p53 downstream targets can collectively modulate apoptotic response to bortezomib and other proteasome inhibitors. Bortezomib tumor protein p53 Homo sapiens