Title : Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression.

Pub. Date : 2004 Jan 13

PMID : 14688410






2 Functional Relationships(s)
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1 Up-regulation of angiogenic regulatory genes in COX-2 transgenic mammary tissue was also potently inhibited by indomethacin treatment, suggesting that prostanoids released from COX-2-expressing mammary epithelial cells induce angiogenesis. Prostaglandins prostaglandin-endoperoxide synthase 2 Mus musculus
2 Up-regulation of angiogenic regulatory genes in COX-2 transgenic mammary tissue was also potently inhibited by indomethacin treatment, suggesting that prostanoids released from COX-2-expressing mammary epithelial cells induce angiogenesis. Prostaglandins prostaglandin-endoperoxide synthase 2 Mus musculus