Pub. Date : 2004 Jan 1
PMID : 14688340
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |
2 | Studies conducted to understand the regulation of AP-1 and NF-kappaB activation by JNK MAPK revealed that both DXM and SP600125 inhibited IL-12p40 gene transcription by inhibiting the activation of AP-1 and NF-kappaB transcription factors as revealed by luciferase reporter and gel mobility shift assays. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |
3 | Taken together, our results suggest that DXM may inhibit IL-12p40 production in LPS-stimulated human monocytic cells by down-regulating the activation of JNK MAPK, the AP-1, and NF-kappaB transcription factors. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |