Title : Pharmacokinetics of etoricoxib in patients with renal impairment.

Pub. Date : 2004 Jan

PMID : 14681341






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1 The effect of renal insufficiency on the pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, was examined in 23 patients with varying degrees of renal impairment (12 moderate [creatinine clearance between 30 and 50 mL/min/1.73 m2], 5 severe [creatinine clearance below 30 mL/min/1.73 m2], and 6 with end-stage renal disease requiring hemodialysis) following administration of single 120-mg oral doses of etoricoxib. Etoricoxib prostaglandin-endoperoxide synthase 2 Homo sapiens