Title : Functional role of the lock and key motif at the subunit interface of glutathione transferase p1-1.

Pub. Date : 2004 Mar 5

PMID : 14676193






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The key residue, which is either Phe or Tyr (Tyr(50) in human GSTP1-1) in one subunit, is wedged into a hydrophobic pocket of the other subunit. Tyrosine glutathione S-transferase pi 1 Homo sapiens
2 The key residue, which is either Phe or Tyr (Tyr(50) in human GSTP1-1) in one subunit, is wedged into a hydrophobic pocket of the other subunit. Tyrosine glutathione S-transferase pi 1 Homo sapiens
3 A network of hydrogen-bonded water molecules, found in crystal structures of GSTP1-1, connects the two active sites and the main chain carbonyl group of Tyr(50), thereby offering a mechanism for communication between the two active sites. Tyrosine glutathione S-transferase pi 1 Homo sapiens