Title : The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2.

Pub. Date : 2003 Dec

PMID : 14671431






1 Functional Relationships(s)
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1 Lonafarnib is shown here to inhibit the function of MRP1 and MRP2 with a potency similar to that of cyclosporin A and may therefore cause the observed synergy with cisplatin and other agents by inhibiting these MRPs. Cisplatin ATP binding cassette subfamily C member 1 Homo sapiens