Title : Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.

Pub. Date : 2003 Nov

PMID : 14667967






2 Functional Relationships(s)
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1 More recently, selective ablation of the PR-A and PR-B proteins in mice had facilitated examination of the contribution of the individual PR isoforms to the pleiotropic reproductive activities of progesterone. Progesterone S100 calcium binding protein A6 (calcyclin) Mus musculus
2 Analysis of the phenotypic consequences of these mutations on female reproductive function has provided proof of concept that the distinct transcriptional responses to PR-A and PR-B observed in cell-based transactivation assays are reflected in a distinct tissue-selective contribution of the individual isoforms to the reproductive activities of progesterone. Progesterone S100 calcium binding protein A6 (calcyclin) Mus musculus