Title : Clinical pharmacology of proton pump inhibitors: what the practising physician needs to know.

Pub. Date : 2003

PMID : 14664653






2 Functional Relationships(s)
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1 However, there are significant genetic polymorphisms for one of the cytochrome P450 (CYP) isoenzymes involved in PPI metabolism (CYP2C19), and this polymorphism has been shown to substantially increase plasma levels of omeprazole, lansoprazole and pantoprazole, but not those of rabeprazole. Rabeprazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 However, there are significant genetic polymorphisms for one of the cytochrome P450 (CYP) isoenzymes involved in PPI metabolism (CYP2C19), and this polymorphism has been shown to substantially increase plasma levels of omeprazole, lansoprazole and pantoprazole, but not those of rabeprazole. Rabeprazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens