Title : Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.

Pub. Date : 2004 Feb 20

PMID : 14660604






3 Functional Relationships(s)
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1 The EGFr inhibitor, tyrphostin AG1478 (1 microM), inhibited both Bt2cAMP/AM-stimulated EGFr phosphorylation and Isc responses. Tyrphostins epidermal growth factor receptor Homo sapiens
2 The EGFr inhibitor, tyrphostin AG1478 (1 microM), inhibited both Bt2cAMP/AM-stimulated EGFr phosphorylation and Isc responses. Tyrphostins epidermal growth factor receptor Homo sapiens
3 VIP and Bt2cAMP/AM both stimulated ERK MAPK phosphorylation and recruitment of the p85 subunit of phosphatidylinositol 3-kinase (PI3K) to the EGFr in a tyrphostin AG1478-sensitive manner. Tyrphostins epidermal growth factor receptor Homo sapiens