Title : Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage.

Pub. Date : 2003 Dec 1

PMID : 14657223






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 7-ketocholesterol rapidly entered the nucleus and activated poly(ADP-ribose)-polymerase (PARP)-1, followed by the expression of migration-regulating integrins CD11a and intercellular adhesion molecule 1. 7-ketocholesterol poly(ADP-ribose) polymerase 1 Homo sapiens