Title : Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors.

Pub. Date : 2004 Apr

PMID : 14657192






4 Functional Relationships(s)
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Protein Name
Organism
1 The reasons for investigating its effects on capsaicin-activated TRPV1 channels are to understand how it may modulate this channel that is involved in pain, inflammation, and gustatory physiology. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
2 Nicotine also modulates TRPV1 receptors inducing a several-fold increase in capsaicin-activated currents in both TG neurons and in cells with heterologously expressed TRPV1 receptors. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
3 Nicotine also modulates TRPV1 receptors inducing a several-fold increase in capsaicin-activated currents in both TG neurons and in cells with heterologously expressed TRPV1 receptors. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
4 In this regard, its effect on TRPV1 receptors differs from those of ethanol that has been shown to increase the capsaicin-activated current but decrease the threshold temperature. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens