Title : Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression.

Pub. Date : 2004 Mar

PMID : 14656721






4 Functional Relationships(s)
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1 Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. Hydrogen Peroxide nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Exposure of LPS- or TNF-alpha-stimulated neutrophils to H2O2 decreased nuclear translocation of NF-kappaB. Hydrogen Peroxide nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 This inhibition of nuclear accumulation of NF-kappaB by H2O2 was not caused by an impaired capacity of LPS to stimulate the IKK pathway or to direct oxidative effects on NF-kappaB but rather reflected diminished degradation of IkappaB-alpha. Hydrogen Peroxide nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
4 This inhibition of nuclear accumulation of NF-kappaB by H2O2 was not caused by an impaired capacity of LPS to stimulate the IKK pathway or to direct oxidative effects on NF-kappaB but rather reflected diminished degradation of IkappaB-alpha. Hydrogen Peroxide nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus