Pub. Date : 2004 Apr
PMID : 14656708
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 2 | We examined whether cGMP-dependent protein kinase (PKG) and mitochondrial ATP-sensitive potassium (K(ATP)) channels are involved in S-nitroso-N-acetyl penicillamine (SNAP)-induced reactive oxygen species (ROS) generation. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 3 | KT-5823, an inhibitor of PKG, prevented ROS generation, indicating that PKG is required for ROS generation. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 4 | KT-5823, an inhibitor of PKG, prevented ROS generation, indicating that PKG is required for ROS generation. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 5 | KT-5823, an inhibitor of PKG, prevented ROS generation, indicating that PKG is required for ROS generation. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 6 | In addition, 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP), an activator of PKG, induced ROS generation. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |
| 7 | These results suggest that SNAP-induced ROS generation is mediated by activation of PKG and mitochondrial K(ATP) channels and that opening of mitochondrial K(ATP) channels is the downstream event of PKG activation. | Reactive Oxygen Species | protein kinase cGMP-dependent 1 | Homo sapiens |