Title : GP7 can induce apoptotic DNA fragmentation of human leukemia cells through caspase-3-dependent and -independent pathways.

Pub. Date : 2004 Jan

PMID : 14654989






2 Functional Relationships(s)
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1 To determine the role of caspase-3 in GP7-induced apoptotic DNA fragmentation, we examined the effect of specific caspase-3 inhibitor, Ac-DEVD-CHO, on GP7-induced apoptotic DNA fragmentation. acetyl-aspartyl-glutamyl-valyl-aspartal caspase 3 Homo sapiens
2 Ac-DEVD-CHO prevented GP7-induced caspase-3 activation in both HL-60 and Jurkat cells, however, it only inhibited GP7-induced apoptotic internucleosomal DNA fragmentation in HL-60 cells. acetyl-aspartyl-glutamyl-valyl-aspartal caspase 3 Homo sapiens