Pub. Date : 2003 Dec
PMID : 14654757
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Entacapone protects from angiotensin II-induced inflammation and renal injury. | entacapone | angiotensinogen | Rattus norvegicus |
| 2 | We tested the hypothesis whether entacapone, a catechol-O-methyltransferase (COMT) inhibitor exerting antioxidative and anti-inflammatory properties, protects against the Ang II-induced inflammatory response and end-organ damage. | entacapone | angiotensinogen | Rattus norvegicus |
| 3 | Entacapone ameliorated Ang II-induced vascular and glomerular damage, leucocyte infiltration, and intercellular adhesion molecule-1 (ICAM-1) overexpression in the kidneys. | entacapone | angiotensinogen | Rattus norvegicus |
| 4 | CONCLUSION: Our findings suggest that entacapone provides protection against Ang II-induced renal damage through antioxidative and anti-inflammatory mechanisms, rather than by COMT inhibition-induced changes in renal dopaminergic tone. | entacapone | angiotensinogen | Rattus norvegicus |