Title : Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist.

Pub. Date : 2004 Jan

PMID : 14654105






2 Functional Relationships(s)
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1 Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in the detection of noxious painful stimuli, such as capsaicin, acid and heat. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
2 In electrophysiological experiments, SB-366791 was demonstrated to be an effective antagonist of hTRPV1 when activated by different modalities, such as capsaicin, acid or noxious heat (50 degrees C). Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens