Title : Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.

Pub. Date : 2003 Dec 3

PMID : 14652237






4 Functional Relationships(s)
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1 BACKGROUND: Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-hydroxy-tamoxifen and other active metabolites by cytochrome P450 (CYP) enzymes. Tamoxifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 BACKGROUND: Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-hydroxy-tamoxifen and other active metabolites by cytochrome P450 (CYP) enzymes. Tamoxifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 To determine which CYP isoforms were involved in the metabolism of tamoxifen to specific metabolites, we used CYP isoform-specific inhibitors. Tamoxifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens
4 To determine which CYP isoforms were involved in the metabolism of tamoxifen to specific metabolites, we used CYP isoform-specific inhibitors. Tamoxifen cytochrome P450 family 4 subfamily F member 3 Homo sapiens