Title : Pyridoxal 5'-phosphate is a selective inhibitor in vivo of DNA polymerase alpha and epsilon.

Pub. Date : 2003 Dec 26

PMID : 14651974






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 PL moderately inhibited only the activities of calf DNA polymerase alpha (pol alpha), while PN and PM had no inhibitory effects on any of the polymerases tested. Pyridoxal DNA polymerase alpha 1, catalytic subunit Homo sapiens
2 PL moderately inhibited only the activities of calf DNA polymerase alpha (pol alpha), while PN and PM had no inhibitory effects on any of the polymerases tested. Pyridoxal DNA polymerase alpha 1, catalytic subunit Homo sapiens
3 Since PL was converted to PLP in vivo after being incorporated into human cancer cells, the anti-angiogenic and anti-cancer effects caused by PL must have been caused by the inhibition of pol alpha and epsilon activities after conversion to PLP. Pyridoxal DNA polymerase alpha 1, catalytic subunit Homo sapiens