Pub. Date : 1998 Dec
PMID : 14646475
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two-dimensional gel analysis of apoptosis-specific p53 isoforms induced by 2-methoxyestradiol in human lung cancer cells. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 2 | The natural metabolic byproduct of estradiol, 2-methoxyestradiol (2-MeOE2), induces apoptosis in human lung cancer cells by a p53-dependent mechanism. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 3 | The natural metabolic byproduct of estradiol, 2-methoxyestradiol (2-MeOE2), induces apoptosis in human lung cancer cells by a p53-dependent mechanism. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 4 | However, when H1299 cells transfected with p53 were treated with 2-MeOE2, they underwent rapid and extensive apoptosis. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 5 | Analysis of wild-type p53 phosphoisoforms in H1299 cells by two-dimensional gel electrophoresis revealed that 2-MeOE2 induced a unique group of acidic p53 isoforms. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 6 | Analysis of wild-type p53 phosphoisoforms in H1299 cells by two-dimensional gel electrophoresis revealed that 2-MeOE2 induced a unique group of acidic p53 isoforms. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 7 | Although most of the wild-type p53 in untreated H1299 cells migrated as at least five diffuse species with isoelectric points from pH 5.5-6.3, as many as nine additional forms migrating toward the acidic region with pI values from 4.4-5.3 were detected in 2-MeOE2-treated apoptotic cells. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |
| 8 | The results indicated that the induction of apoptosis in H1299 cells by 2-MeOE2 is dependent on the upregulation of specific p53 isoforms. | 2-Methoxyestradiol | tumor protein p53 | Homo sapiens |