Pub. Date : 2003 Dec
PMID : 14645667
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Because BCL2-family proteins are important in apoptosis induced by chemotherapeutic drugs, GADD153 may be a key mediator of synergy between fenretinide and chemotherapeutic drugs. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
2 | Increased expression of GADD153 raised the background level of apoptosis and increased apoptosis induced by fenretinide or the chemotherapeutic drugs cisplatin and etoposide. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
3 | Conversely, expression of antisense-GADD153 virtually abolished the induction of apoptosis in response to fenretinide but overall had no significant effect on apoptosis induced by chemotherapeutic drugs. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
4 | The effect of antisense-GADD153 on synergy between chemotherapeutic drugs and fenretinide varied with the drug used: there was no effect on synergy between fenretinide and cisplatin, but the combination of fenretinide with etoposide became antagonistic. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |
5 | These results suggest that mechanisms mediating synergy between fenretinide and chemotherapeutic drugs lie upstream of GADD153. | Fenretinide | DNA damage inducible transcript 3 | Homo sapiens |