Title : Growth and DNA damage-inducible transcription factor 153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma.

Pub. Date : 2003 Dec

PMID : 14645667






5 Functional Relationships(s)
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1 Because BCL2-family proteins are important in apoptosis induced by chemotherapeutic drugs, GADD153 may be a key mediator of synergy between fenretinide and chemotherapeutic drugs. Fenretinide DNA damage inducible transcript 3 Homo sapiens
2 Increased expression of GADD153 raised the background level of apoptosis and increased apoptosis induced by fenretinide or the chemotherapeutic drugs cisplatin and etoposide. Fenretinide DNA damage inducible transcript 3 Homo sapiens
3 Conversely, expression of antisense-GADD153 virtually abolished the induction of apoptosis in response to fenretinide but overall had no significant effect on apoptosis induced by chemotherapeutic drugs. Fenretinide DNA damage inducible transcript 3 Homo sapiens
4 The effect of antisense-GADD153 on synergy between chemotherapeutic drugs and fenretinide varied with the drug used: there was no effect on synergy between fenretinide and cisplatin, but the combination of fenretinide with etoposide became antagonistic. Fenretinide DNA damage inducible transcript 3 Homo sapiens
5 These results suggest that mechanisms mediating synergy between fenretinide and chemotherapeutic drugs lie upstream of GADD153. Fenretinide DNA damage inducible transcript 3 Homo sapiens