Title : Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cell activation.

Pub. Date : 2003 Dec

PMID : 14645155






2 Functional Relationships(s)
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1 Reduced CD154 promoter activity by neonatal cells persisted when proximal signaling events were bypassed using ionomycin and PMA, suggesting an additional and more distal mechanism for decreased transcription. Tetradecanoylphorbol Acetate CD40 ligand Homo sapiens
2 In contrast, CD154 mRNA stability was similar in neonatal and adult cells after either ionomycin and PMA stimulation or engagement of the alphabeta TCR-CD3 complex. Tetradecanoylphorbol Acetate CD40 ligand Homo sapiens