Title : Hydrogen peroxide increases a 55-kDa tyrosinase concomitantly with induction of p53-dependent p21 waf1 expression and a greater Bax/Bcl-2 ratio in pigmented melanoma.

Pub. Date : 2003 Dec 12

PMID : 14637145






2 Functional Relationships(s)
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1 Hydrogen peroxide increases a 55-kDa tyrosinase concomitantly with induction of p53-dependent p21 waf1 expression and a greater Bax/Bcl-2 ratio in pigmented melanoma. Hydrogen Peroxide tumor protein p53 Homo sapiens
2 Together, these data suggest that response to hydrogen peroxide involves p53-mediated growth-restrictive signaling and unequal induction of specific DOPA oxidases in melanocytic cells with unequal basal pigmentation. Hydrogen Peroxide tumor protein p53 Homo sapiens