Title : P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1.

Pub. Date : 2003 Dec 9

PMID : 14634213






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis. coumarin tumor protein p53 Homo sapiens
2 We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis. coumarin tumor protein p53 Homo sapiens