Title : Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells.

Pub. Date : 2003 Nov 15

PMID : 14633709






2 Functional Relationships(s)
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1 Moreover, the direct treatment of MCF-10A cells with hydrogen peroxide enhanced EGFR, Akt, and extracellular-regulated kinase phosphorylation that could be similarly inhibited by AG1478, N-acetyl cysteine, and catalase. Hydrogen Peroxide epidermal growth factor receptor Homo sapiens
2 Taken together, these data indicate that BPQs, through the generation of hydrogen peroxide, activate the EGFR in MCF-10A cells, leading to increased cell number under EGF-deficient conditions. Hydrogen Peroxide epidermal growth factor receptor Homo sapiens