Title : Ganglioside GM1 binding toxins and human neuropathy-associated IgM antibodies differentially promote neuritogenesis in a PC12 assay.

Pub. Date : 2003 Dec

PMID : 14630342






2 Functional Relationships(s)
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1 PC12 cells undergo neuritogenesis upon nerve growth factor (NGF) activation of the TrkA receptor, an effect mimicked by the ganglioside GM1 binding B-subunit of cholera toxin (CTB). G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens
2 These data indicate that GM1/ligand interaction does not necessarily lead to neuritogenesis and suggest that a specialisation of CTB, not shared by anti-GM1 antibodies or rETxB, is required to activate TrkA. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Homo sapiens