Title : Structures of calcineurin and its complexes with immunophilins-immunosuppressants.

Pub. Date : 2003 Nov 28

PMID : 14623295






2 Functional Relationships(s)
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1 The crystal structures of CN and its complexes with FKBP12-FK506 and cyclophilin-cyclosporin showed that the two structurally unrelated immunophilins-immunosuppressants bind to a common composite surface made up of the residues from both catalytic subunit and regulatory subunit of CN. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens
2 However, the binding pattern of FKBP12-FK506 such as hydrogen bonding is significantly different from that of CyPA-CsA. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens