Title : The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the spinal cord after intradermal injection of capsaicin.

Pub. Date : 2002 Jun

PMID : 14622772






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the spinal cord after intradermal injection of capsaicin. Capsaicin cAMP responsive element binding protein 1 Homo sapiens
2 The level of p-CREB increased by 20 minutes, peaked between 20 and 60 minutes after capsaicin injection, and started to decrease after 150 minutes. Capsaicin cAMP responsive element binding protein 1 Homo sapiens
3 The p-CREB expression on the ipsilateral side of the spinal dorsal horn, but not on the contralateral side, increased significantly after capsaicin injection. Capsaicin cAMP responsive element binding protein 1 Homo sapiens
4 The increase in p-CREB induced by capsaicin injection was partially blocked by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, administered through a microdialysis fiber placed across the spinal cord. Capsaicin cAMP responsive element binding protein 1 Homo sapiens