Title : Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.

Pub. Date : 2003 Nov

PMID : 14622273






1 Functional Relationships(s)
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1 E2020 (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl)piperidine hydrochloride is a piperidine-based acetylcholinesterase (AChE) inhibitor that was approved for the treatment of Alzheimer"s disease in the United States. piperidine acetylcholinesterase (Cartwright blood group) Homo sapiens