Pub. Date : 2003 Oct
PMID : 14620918
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bisphosphonate induced growth inhibition of breast cancer cells is augmented by p38 inhibition. | Diphosphonates | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | MDA-MB-231 cells stably expressing a dominant negative form of the p38 MAP kinase (p38/AF) exhibited a dramatic increase in growth inhibition in response to BPs in vitro, compared to control cells. | Diphosphonates | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | MDA-MB-231 cells stably expressing a dominant negative form of the p38 MAP kinase (p38/AF) exhibited a dramatic increase in growth inhibition in response to BPs in vitro, compared to control cells. | Diphosphonates | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | SB203580, a specific inhibitor of the p38 MAP kinase, also augmented BP-induced growth inhibition of parental MDA-MB-231 cells. | Diphosphonates | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | In conclusion, these results suggest that BPs activate the p38 pathway in MDA-MB-231 and J774 cells. | Diphosphonates | mitogen-activated protein kinase 14 | Homo sapiens |
| 6 | This activation may be associated with increased survival or proliferation because inhibition of p38 augments BP-induced growth inhibition. | Diphosphonates | mitogen-activated protein kinase 14 | Homo sapiens |