Title : Bisphosphonate induced growth inhibition of breast cancer cells is augmented by p38 inhibition.

Pub. Date : 2003 Oct

PMID : 14620918






6 Functional Relationships(s)
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Protein Name
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1 Bisphosphonate induced growth inhibition of breast cancer cells is augmented by p38 inhibition. Diphosphonates mitogen-activated protein kinase 14 Homo sapiens
2 MDA-MB-231 cells stably expressing a dominant negative form of the p38 MAP kinase (p38/AF) exhibited a dramatic increase in growth inhibition in response to BPs in vitro, compared to control cells. Diphosphonates mitogen-activated protein kinase 14 Homo sapiens
3 MDA-MB-231 cells stably expressing a dominant negative form of the p38 MAP kinase (p38/AF) exhibited a dramatic increase in growth inhibition in response to BPs in vitro, compared to control cells. Diphosphonates mitogen-activated protein kinase 14 Homo sapiens
4 SB203580, a specific inhibitor of the p38 MAP kinase, also augmented BP-induced growth inhibition of parental MDA-MB-231 cells. Diphosphonates mitogen-activated protein kinase 14 Homo sapiens
5 In conclusion, these results suggest that BPs activate the p38 pathway in MDA-MB-231 and J774 cells. Diphosphonates mitogen-activated protein kinase 14 Homo sapiens
6 This activation may be associated with increased survival or proliferation because inhibition of p38 augments BP-induced growth inhibition. Diphosphonates mitogen-activated protein kinase 14 Homo sapiens