Title : The role of the androgen receptor in the development of prostatic hyperplasia and prostate cancer.

Pub. Date : 2003 Nov

PMID : 14619959






2 Functional Relationships(s)
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1 These changes confer growth advantage to the tumor cells due to either hypersensitivity of AR to low, castrate-level androgens or a realignment of the receptor conformation, leading to altered ligand specificity that enables antiandrogens, adrenal androgens and non-androgen steroids act agonistically to increase AR activity. Steroids androgen receptor Homo sapiens
2 These changes confer growth advantage to the tumor cells due to either hypersensitivity of AR to low, castrate-level androgens or a realignment of the receptor conformation, leading to altered ligand specificity that enables antiandrogens, adrenal androgens and non-androgen steroids act agonistically to increase AR activity. Steroids androgen receptor Homo sapiens