Title : Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine.

Pub. Date : 2004 Mar

PMID : 14615284






4 Functional Relationships(s)
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1 Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine. Thiamine solute carrier family 19 member 3 Homo sapiens
2 Pretreating Caco-2 cells (which also express the hTHTR-2 at RNA and protein levels) with hTHTR-2 gene-specific small interfering RNA (siRNA) led to a significant (P < 0.01) and specific inhibition (48%) in carrier-mediated thiamin uptake. Thiamine solute carrier family 19 member 3 Homo sapiens
3 Pretreating Caco-2 cells (which also express the hTHTR-2 at RNA and protein levels) with hTHTR-2 gene-specific small interfering RNA (siRNA) led to a significant (P < 0.01) and specific inhibition (48%) in carrier-mediated thiamin uptake. Thiamine solute carrier family 19 member 3 Homo sapiens
4 When Caco-2 cells were pretreated with siRNAs against both hTHTR-2 and hTHTR-1 genes, an almost complete inhibition in carrier-mediated thiamin uptake was observed. Thiamine solute carrier family 19 member 3 Homo sapiens