Title : Induction of apoptosis in BCR/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF/MEK/ERK and JNK pathways.

Pub. Date : 2003 Sep-Oct

PMID : 14614324






1 Functional Relationships(s)
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1 Together, these findings support a model in which induction of apoptosis in Bcr/Abl+ cells by HDIs involves coordinate inactivation of the cytoprotective Raf/MEK/ERK pathway in conjunction with the ROS-dependent activation of JNK. ros mitogen-activated protein kinase 8 Homo sapiens