Title : Reduced histone biotinylation in multiple carboxylase deficiency patients: a nuclear role for holocarboxylase synthetase.

Pub. Date : 2004 Jan 1

PMID : 14613969






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The attachment of biotin to apocarboxylases is catalyzed by holocarboxylase synthetase (HCS). Biotin holocarboxylase synthetase Homo sapiens
2 The attachment of biotin to apocarboxylases is catalyzed by holocarboxylase synthetase (HCS). Biotin holocarboxylase synthetase Homo sapiens
3 We propose that the role of HCS in histone modification may be linked to the participation of biotin in the regulation of gene expression or cell division and that affected patients may have additional disease beyond that due to the effect on carboxylases. Biotin holocarboxylase synthetase Homo sapiens