Title : Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver.

Pub. Date : 2003 Nov 15

PMID : 14613719






2 Functional Relationships(s)
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1 We have previously used CYP1B1-null mice to demonstrate that dimethylbenz(a)anthracene (DMBA) requires CYP1B1 for bone marrow (BM) toxicity. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus
2 We have previously used CYP1B1-null mice to demonstrate that dimethylbenz(a)anthracene (DMBA) requires CYP1B1 for bone marrow (BM) toxicity. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus