Pub. Date : 2003 Nov 1
PMID : 14612532
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells. | Bortezomib | tumor protein p53 | Homo sapiens |
2 | Bortezomib induced strong stabilization of p53, but it did not promote phosphorylation on serines 15 and 20, and p53 remained bound to its inhibitor, mdm2. | Bortezomib | tumor protein p53 | Homo sapiens |
3 | Nonetheless, bortezomib stimulated p53 translocation to the nucleus (not mitochondria) and enhanced p53 DNA binding, accumulation of p53-dependent transcripts, and activation of a p53-responsive reporter gene. | Bortezomib | tumor protein p53 | Homo sapiens |
4 | Nonetheless, bortezomib stimulated p53 translocation to the nucleus (not mitochondria) and enhanced p53 DNA binding, accumulation of p53-dependent transcripts, and activation of a p53-responsive reporter gene. | Bortezomib | tumor protein p53 | Homo sapiens |
5 | Nonetheless, bortezomib stimulated p53 translocation to the nucleus (not mitochondria) and enhanced p53 DNA binding, accumulation of p53-dependent transcripts, and activation of a p53-responsive reporter gene. | Bortezomib | tumor protein p53 | Homo sapiens |
6 | Nonetheless, bortezomib stimulated p53 translocation to the nucleus (not mitochondria) and enhanced p53 DNA binding, accumulation of p53-dependent transcripts, and activation of a p53-responsive reporter gene. | Bortezomib | tumor protein p53 | Homo sapiens |
7 | Furthermore, stable LNCaP-Pro5 transfectants of LNCaP-Pro5 expressing the p53 inhibitor human papillomavirus-E6 displayed reduced bortezomib-induced p53 activation and cell death. | Bortezomib | tumor protein p53 | Homo sapiens |
8 | Furthermore, stable LNCaP-Pro5 transfectants of LNCaP-Pro5 expressing the p53 inhibitor human papillomavirus-E6 displayed reduced bortezomib-induced p53 activation and cell death. | Bortezomib | tumor protein p53 | Homo sapiens |
9 | Together, our data demonstrate that bortezomib stimulates p53 activation via a novel mechanism. | Bortezomib | tumor protein p53 | Homo sapiens |