Title : Cage amines as the stopper inhibitors of cholinesterases.

Pub. Date : 2003 Sep 1

PMID : 14611850






2 Functional Relationships(s)
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1 Cage amines 1-4 are potent peripheral anionic site-bound reversible inhibitors of both acetylcholinesterase and butyrylcholinesterase. Amines acetylcholinesterase (Cartwright blood group) Homo sapiens
2 For both enzymes, the -log K(i) values linearly correlate with the difference of substituted phenyl radius of cage amines (-log K(i)=5.4+3.4Deltagamma for acetylcholinesterase, -log K(i)=5.9+3.2Deltagamma for butyrylcholinesterase). Amines acetylcholinesterase (Cartwright blood group) Homo sapiens