Pub. Date : 2003 Dec 1
PMID : 14609743
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro susceptibility of CD4+ and CD8+ T cell subsets to fludarabine. | fludarabine | CD4 molecule | Homo sapiens |
| 2 | Administration of the adenosine analogue fludarabine (FLU) in vivo induces a profound and prolonged T lymphopenia which mainly affects CD4(+) cells. | fludarabine | CD4 molecule | Homo sapiens |
| 3 | Administration of the adenosine analogue fludarabine (FLU) in vivo induces a profound and prolonged T lymphopenia which mainly affects CD4(+) cells. | fludarabine | CD4 molecule | Homo sapiens |
| 4 | Contrasting with observations in vivo, our results showed that treatment of peripheral blood mononuclear cells with FLU induced a higher level of apoptosis in CD8(+) than in CD4(+) T lymphocytes. | fludarabine | CD4 molecule | Homo sapiens |
| 5 | This increased sensitivity of CD8(+) T cells to FLU was observed in samples from both, healthy donors and B cell chronic lymphocytic leukemia patients, and resulted in higher CD4:CD8 ratios in FLU-treated than in untreated cultures (P<0.01). | fludarabine | CD4 molecule | Homo sapiens |
| 6 | This increased sensitivity of CD8(+) T cells to FLU was observed in samples from both, healthy donors and B cell chronic lymphocytic leukemia patients, and resulted in higher CD4:CD8 ratios in FLU-treated than in untreated cultures (P<0.01). | fludarabine | CD4 molecule | Homo sapiens |
| 7 | These results favor the view that decreased CD4:CD8 ratios in FLU-treated patients should be attributed to differences in cell recovery and/or homing between T cell subsets. | fludarabine | CD4 molecule | Homo sapiens |