Pub. Date : 2003 Nov
PMID : 14608048
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |
| 2 | Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |
| 3 | Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |
| 4 | Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |
| 5 | Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |
| 6 | Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |
| 7 | Mice with a homozygous disruption of the PEMT gene are dependent on the 1,2-diacylglycerol cholinephosphotransferase (CDP-choline) pathway for the synthesis of PC and develop severe liver steatosis when fed a diet deficient in choline. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |
| 8 | These findings indicate that PEMT activity functions beyond its recognized role as a compensatory pathway for PC biosynthesis and that, in contrast, PEMT activity is involved in many physiologic processes including the flux of lipid between liver and plasma and the delivery of essential fatty acids to blood and peripheral tissues via the liver-derived lipoproteins. | Phosphatidylcholines | phosphatidylethanolamine N-methyltransferase | Mus musculus |