Title : Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.

Pub. Date : 1992 Dec 15

PMID : 1460280






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 De novo protein synthesis is not required for TNF-alpha expression because the inclusion of cycloheximide does not prevent expression of the gene and acts to superinduce TNF-alpha mRNA levels. Cycloheximide tumor necrosis factor Rattus norvegicus
2 Cycloheximide acts to increase both transcription of the TNF-alpha gene and stability of TNF-alpha mRNA thereby resulting in increased TNF-alpha steady state mRNA levels. Cycloheximide tumor necrosis factor Rattus norvegicus
3 Cycloheximide acts to increase both transcription of the TNF-alpha gene and stability of TNF-alpha mRNA thereby resulting in increased TNF-alpha steady state mRNA levels. Cycloheximide tumor necrosis factor Rattus norvegicus
4 Cycloheximide acts to increase both transcription of the TNF-alpha gene and stability of TNF-alpha mRNA thereby resulting in increased TNF-alpha steady state mRNA levels. Cycloheximide tumor necrosis factor Rattus norvegicus