Pub. Date : 2004 Jan 30
PMID : 14602724
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we report that insulin (0.5-200 nmol/liter) interferes with agonist-induced increases in [Ca(2+)](i) (ADP, thrombin), cAMP suppression (thrombin), and aggregation (ADP). | Cyclic AMP | insulin | Homo sapiens |
| 2 | The effects of insulin are as follows: (i) independent of the P2Y(12) receptor, which mediates ADP-induced cAMP lowering; (ii) not observed during G(s)-mediated cAMP formation; (iii) unaffected by treatments that affect phosphodiesterases (3-isobutyl-1-methylxanthine); and (iv) not changed by interfering with NO-mediated regulation of cAMP degradation (N(G)-monomethyl-l-arginine). | Cyclic AMP | insulin | Homo sapiens |
| 3 | We conclude that insulin attenuates platelet functions by interfering with cAMP suppression through IRS-1 and G(i). | Cyclic AMP | insulin | Homo sapiens |