Title : Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells.

Pub. Date : 2003 Dec 20

PMID : 14601052






4 Functional Relationships(s)
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1 Here, we report that while ActD, DOX and CDDP sensitised both OS and Ewing"s tumour cell lines and normal cells (hOBs, synovial cells, fibroblasts) to TRAIL/Apo2L-induced apoptosis, the combination of etoposide (VP16) and TRAIL/Apo2L was selectively active on tumour cells without affecting normal cells. Etoposide TNF superfamily member 10 Homo sapiens
2 Here, we report that while ActD, DOX and CDDP sensitised both OS and Ewing"s tumour cell lines and normal cells (hOBs, synovial cells, fibroblasts) to TRAIL/Apo2L-induced apoptosis, the combination of etoposide (VP16) and TRAIL/Apo2L was selectively active on tumour cells without affecting normal cells. Etoposide TNF superfamily member 10 Homo sapiens
3 Here, we report that while ActD, DOX and CDDP sensitised both OS and Ewing"s tumour cell lines and normal cells (hOBs, synovial cells, fibroblasts) to TRAIL/Apo2L-induced apoptosis, the combination of etoposide (VP16) and TRAIL/Apo2L was selectively active on tumour cells without affecting normal cells. Etoposide TNF superfamily member 10 Homo sapiens
4 Here, we report that while ActD, DOX and CDDP sensitised both OS and Ewing"s tumour cell lines and normal cells (hOBs, synovial cells, fibroblasts) to TRAIL/Apo2L-induced apoptosis, the combination of etoposide (VP16) and TRAIL/Apo2L was selectively active on tumour cells without affecting normal cells. Etoposide TNF superfamily member 10 Homo sapiens