Title : Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes.

Pub. Date : 2003 Oct-Dec

PMID : 14599481






2 Functional Relationships(s)
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1 By contrast ROS formation by LD50 concentrations of Cu(II), Ni(II), Co(II) or dichromate [Cr(VI)] were not affected by uncouplers or glycolytic substrates. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 In conclusion, lysosomes are sites of cytotoxic ROS formation with redox transition metals (CuII, CrVI, NiII, CoII) whereas mitochondria are the ROS sites for non-redox or poor redox cycling transition metals (CdII, HgII, AsIII). Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens