Pub. Date : 2003 Nov 11
PMID : 14597699
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we report NADPH oxidase-dependent reactive oxygen species (ROS) production and extracellular regulated kinases 1/2 (ERK1/2) phosphorylation on PrPC stimulation in the 1C11 neuroectodermal precursor, in its neuronal differentiated progenies, and in GT1-7 neurohypothalamic and BW5147 lymphoid cells. | Reactive Oxygen Species | prion protein | Mus musculus |
| 2 | In 1C11-derived bioaminergic cells, ROS signaling and ERK1/2 phosphorylation are both controlled by Fyn kinase activation, introducing some specificity in PrPC transduction associated with this neuronal context. | Reactive Oxygen Species | prion protein | Mus musculus |
| 3 | These data argue for an ubiquitous function of PrPC in cell-redox homeostasis through ROS production. | Reactive Oxygen Species | prion protein | Mus musculus |