Title : Involvement of NMDA receptors in Zif/268 expression in the trigeminal nucleus caudalis following formalin injection into the rat whisker pad.

Pub. Date : 2003 Nov 15

PMID : 14596893






3 Functional Relationships(s)
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1 To this purpose, the effect of the administration of MK-801, an NMDA receptor antagonist, on Zif/268 and c-Fos expression following a noxious stimulus, represented by formalin injection into the whisker pad of rats, was examined in neurons of the trigeminal nucleus caudalis. Dizocilpine Maleate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Zif/268 or c-Fos immunoreactivity elicited by formalin injection was significantly reduced by pretreatment with MK-801 in the superficial layer of the trigeminal nucleus caudalis; more than 40% of the neurons expressing Zif/268 and c-Fos in this layer were also immunolabeled by NR1. Dizocilpine Maleate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 Zif/268 or c-Fos immunoreactivity elicited by formalin injection was significantly reduced by pretreatment with MK-801 in the superficial layer of the trigeminal nucleus caudalis; more than 40% of the neurons expressing Zif/268 and c-Fos in this layer were also immunolabeled by NR1. Dizocilpine Maleate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus